A probably fatal symptom sophisticated sometimes called Neuroleptic Malignant Syndrome (NMS) continues to be noted in association with Promethazine HCl by yourself or together with antipsychotic medication.
Excessively big dosages of antihistamines, which include promethazine hydrochloride, in pediatric people might induce unexpected death (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric sufferers. In pediatric patients who're acutely unwell associated with dehydration, There may be an increased susceptibility to dystonias with using promethazine HCl.
Respiration challenges (respiratory melancholy)that can result in death and opioid withdrawal can happen if You begin getting or end having other medicines whilst using Promethazine Hydrochloride and Codeine Phosphate Oral Option, which includes:
Therapy adjunctive to meperidine or other analgesics for control of postoperative discomfort. Sedation in each small children and Grown ups, along with relief of apprehension and manufacture of light snooze from which the affected person can be quickly aroused.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 6 years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and at times Dying, in pediatric sufferers.
Codeine is known being considerably excreted by the kidney, and the potential risk of adverse reactions to this drug could possibly be higher in clients with impaired renal operate.
Promethazine HCl may very well be employed on your own or as an adjunct to narcotic analgesics during labor (see DOSAGE AND ADMINISTRATION). Minimal facts suggest that utilization of Promethazine throughout labor and supply doesn't have an appreciable effect on the length of labor or delivery and does not enhance the possibility of need for intervention from the new child.
Advise people to constantly use an accurate milliliter measuring machine when measuring and administering Promethazine HCl and Codeine Phosphate Oral Option. Notify patients that a family teaspoon is not an correct measuring device and such use could lead on to overdosage and major adverse reactions [see Overdosage (10)].
Just after initiation of procedure in children or Grownups, dosage really should be modified on the smallest amount satisfactory To alleviate indications. The administration of Promethazine HCl in 25-mg doses will Handle insignificant transfusion reactions of an allergic nature.
two) Spot the mixture inside a sealable bag, vacant can, or other container to avoid the drug from leaking or breaking out of a garbage bag, or to dispose of in accordance with nearby condition pointers and/or laws.
It can be strongly proposed that an precise measuring machine be utilized. A pharmacist can provide an appropriate machine and can provide instructions for measuring the right dose.
Treatment method: The treatment method of overdosage with promethazine and codeine is actually symptomatic and supportive. Only in cases of extreme overdosage or individual sensitivity do very important indicators which includes respiration, pulse, blood pressure level, temperature, and EKG must be monitored. Activated charcoal orally or by lavage might be given, click here or sodium or magnesium sulfate orally to be a cathartic. Attention need to be supplied into the reestablishment of ample respiratory exchange as a result of provision of the patent airway and establishment of assisted or managed ventilation.
The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and somewhat soluble in Liquor.
On the other hand, codeine have to be administered only under shut supervision to sufferers having a record of drug abuse or dependence.